Alignment of P2D ATPases (Na+/Ca2+)
The alignment was performed on The Danish Biotechnological Database with the programme CLUSTALW with default settings. The alignment was refined by hand.
The grouping of P-type ATPases and the nomenclature is adopted from the work described in
Axelsen, K.B. & Palmgren, M.G. (1998) J. Mol. Evol. 46: 84-101.
The sequence numbers refer to the position of the sequence in a phylogenetic tree of P-type ATPases.
The sequences with sequence numbers in parantheses are not included in the phylogenetic tree, but show more than 90 % sequence identity with the sequence with the specified number.
The positions of the transmembrane helices are predicted with the TMHMM server at The Center for Biological Sequence Analysis and the method of von Heijne. The positions might, therefore, be slightly different in the proteins in vivo.
The segments a-h conserved in all P-type ATPases are the amino acid stretches used for the phylogenetic analysis.
Amino acids in the alignment shown in CAPITALS are present in 88% (7 of 8) of theP2D ATPases .
Number Accession Organism Name
used number 1 100 101 200 201 300 301 400 401 500 501 600 601 700 701 800 801 900 901 1000 1001 1100 1101 1180
- O61136 Leishmania donovani CA1 ...........mnfgdeqgd eptpdaydakdkfwaLalen vfnlvqledplaGidaadap rhakelGdNvipikggpswi vilasQfkNAitiVLlIvii IsgvfgDWaefGVvlFilff NallGfyQEygAerslaSLk qmtagvAkViRnGipeiIfi deVVvGDvivleqGasvPAD cRifesnglevDEaLLTGEa LPVvKhanvird.penrlal GDRkNmvyrntqVtqGRgka vVvaggLntemGklAkrLnd sk..gsgk............ .................... ..TaLmkKLdymmyfLFlcc avaAviVfAankmrytpatl sYAtaVAiailPeSLcaViT vaMtfsvkrMaqqkcIVRKL pvLEvLGnvtDICSDKTGTL TenKMvvkkavIgvddvysv ggap...........ydthg dffpamrngq.......... .eqqpvnmahqqevryiyqf LkcAaLcsttvlhvs...ee dmdslagnGnpTEIAIqVmt wkag......lnrdkleeeg ..................we citEysFDSkiKRMStawen kakrelylctKGApErvvel Ctykise........dgklv sLtqqDreqvdqhirdLaaq GLRticFAyredatkifpip aeepfidaydRdqvErdLvF lGivGIYDPPRpEsrpsVva cqhAGIcVrMLTGDhtsTAg sIAsmlnIirrrdldd..pv k..lq.agpdFDkvdpetiD gwadLPvVvgRCsPesKVkM IEsLHRRkKvvAMTGDGfND SPSiKiAdiGcAMG.sGvDV tKgvaDlVitDDNFatIvkA vaEGRRisqcIrKFVvhLLs sNVAeviaLicGLpishg.G eSVFiLSPiEiLWlnmfTSa pPAtGLsldrAtdDilqvpP n..tqgfFTiElIaDtvvYG fwlgaitlcgFavvlYGfks GpegtdCnrhngvg...Cdn iwtaRStaFgilyfglLihs ytvrhprvSiFrmr...... ..w.......ldNkwiFgSc vlggalfvPiVYInaIahgl FvHsmItwEWGviavgvmtF laicEtyKviKnlifpirkv lvevdEeeaEdve.eqrqre Yntftrtmpddrnveriane nlrmsfaslagsvatantgs frvpaqrqkkkriglfrkre
93 P22189 Schizosaccharomyces pombe CTA3 / SPBC24E9.06 ...........mvtinisn. ...........pvyfsdikd vesefl.TsipnGLtheeaq nrLseyGeNrLeadsgvsaw kvllrQvlNAMcvVLilaaa lsfgttDWIeGGVIsaiivl NitvGfiQEyKAeKTMdSLr tLaSPmAhVtRssktdaIds hllVpGDvvvlktGDvvPAD LRLvetvNfeTDEaLLTGES LPViKdahatfq.mnedvpi GDRiNlAySSSiVtKGRakG IcyaTgmqtqIGaiAagLrq kg..klfqrpekdepnyrrk lnkyylkvtsyyvqrvLGln vGTPLqRKLtvLAyiLFcia iilAiiVmAahsfhVtneVs IYAislgiSiIPeSLiaVLs ITMamGqknMskrrVIVRKL eaLEALGgvtDICSDKTGTi TqGKMitRrvWIPsyGylsv dtsdann.........ptig tvsgleaamqd...vlkekk qemkn.idpsnqpsdqFipl LktcaLcNlstvnqt..... etgeWvvkGepTEIAlhVFs krfn......ygkedllktn ...................t fvrEyPFDSeiKRMaviyed qqgq.ytvYaKGAvEriler Cstsngs............. tLeepDrelIiaqmetLaae GLRVLalAtkvidkadnwet ........lpRdvaEssLeF vsLvGIYDPPRtEskgaVel cHrAGIrVHMLTGDhpeTAK AIArEVGIiPpfisdr.dpn mswMvMtgsqFDaLsdeevD sLkaLcLVIaRCaPQTKVkM IEALHRRkaFvAMTGDGVND SPSLKqAnVGIAMGqNGSDV aKdASDIVLtDDNFsSIvNA iEEGRRMfdNImrFVLhLLv sNVgevilLvvGLaFrDevh lSVFpmSPVEiLWcnmiTSs FPsMGLGmElAqpDvmerlP hdnkvgIFqkslIvDmmvYG fflgvvslmtwvvimYGfgt GnLsydCnahyhag...Cnd VfkaRSavFAvvTfCiLimA vEvknfdnSlFnlhgipwge wnfryflhtlveNkFLaWai alaavsvFPtiYIPVINrdV FkHtyIGwEWGvvavavmfy ffyvEiwKsirRsltnpqk. ..kgkfrrtlsntitteskl sekdlehrlflqsrra.... .................... ....................
94 P13587 Saccharomyces cerevisiae ENA1 / ydr040c .........mgegttkennn aefn.......ayhtLtaee aaefig.TslteGLtqdefv hrLktvGeNtLgddtkidyk amvlhQvcNAMimVLlIsmi IsfamhDWItGGVIsFviav NvliGlvQEyKAtKTMnSLk nLsSPnAhViRnGksetIns kdVVpGDiclvkvGDtiPAD LRLietkNfdTDEsLLTGES LPVsKdanlvfg.keeetsv GDRlNlAfSSSaVvKGRakG IVikTaLnseIGkiAksLqg ds..glisrdpsks...... wlqntwistkkvtgafLGtn vGTPLhRKLskLAvlLFwia vlfAiiVmAsqkfdVdkrVa IYAicVAlSmIPsSLvvVLT ITMsvGaavMvsrnVIVRKL dsLEALGavnDICSDKTGTL TqGKMlaRqiWIPrfGtiti snsddpfnpnegnvsliprf spyeyshnedgdvgilqnfk drlyekdlpedidmdlFqkw LetAtLaNiatvfkd....d atdcWkahGdpTEIAIqVFa tkmdlphnaltgekstnqsn endqsslsqhnekpgsaqfe hiaEfPFDStvKRMSsvyyn nhnetyniYgKGAfEsiisc Csswygk.......dgvkit pLtdcDvetIrknvysLsne GLRVLgFAsksftkdqvndd qlk..nitsnRataEsdLvF lGLiGIYDPPRnEtagaVkk fHqAGInVHMLTGDfvgTAK AIAqEVGIlPtnlyhysqei vdsMvMtgsqFDgLseeevD dLpvLPLVIaRCsPQTKVrM IEALHRRkKFctMTGDGVND SPSLKmAnVGIAMGiNGSDV sKeASDIVLsDDNFaSIlNA vEEGRRMtdNIqKFVLqLLa eNVAqalyLiiGLvFrDenG kSVFpLSPVEvLWiivvTSc FPAMGLGlEkAapDlmdrpP hdsevgIFTwEvIiDtfaYG iimtgscmasFtgslYGins GrLghdCdgtynss...Crd VyrsRSaaFAtmTwCaLilA wEvvdmrrSfFrmhpdtdsp ..vkeffrsiwgNqFLFWSi ifgfvsaFPvVYIPVINdkV FlHkpIGaEWGlaiaftiaF wigaElyKcgKRryfktqr. .ahnpEndlEsnnkrdpfea Yststtihtevnigikq... .................... ....................
(94) Q01896 Saccharomyces cerevisiae ENA2 / ydr039c .........msegtvkennn eefn.......ayhtLttee aaefig.TslteGLtqdesl rrLkavGeNtLgddtkidyk amvlhQvcNAMimVLvIsma IsfavrDWItGGVIsFviav NvliGlvQEyKAtKTMnSLk nLsSPnAhViRnGksetIns kdVVpGDiclvkvGDtiPAD LRLietkNfdTDEsLLTGES LPVsKdanlvfg.keeetsv GDRlNlAfSSSaVvKGRakG IVikTaLnseIGkiAksLqg ds..glisrdpsks...... wlqntwistkkvtgafLGtn vGTPLhRKLskLAvlLFwia vlfAiiVmAsqkfdVdkrVa IYAicVAlSmIPsSLvvVLT ITMsvGaavMvsrnVIVRKL dsLEALGavnDICSDKTGTL TqGKMlaRqiWIPrfGtiti snsddpfnpnegnvsliprf spyeyshnedgdvgilqnfk drlyekdlpedidmdlFqkw LetAtLaNiatvfkd....d atdcWkahGdpTEIAIqVFa tkmdlphnaltgekstnqsn endqsslsqhnekpgsaqfe hiaEfPFDStvKRMSsvyyn nhnetyniYgKGAfEsiisc Csswygk.......dgvkit pLtdcDvetIrknvysLsne GLRVLgFAsksftkdqvndd qlk..nitsnRataEsdLvF lGLiGIYDPPRnEtagaVkk fHqAGInVHMLTGDfvgTAK AIAqEVGIlPtnlyhysqei vdsMvMtgsqFDgLseeevD dLpvLPLVIaRCsPQTKVrM IEALHRRkKFcAMTGDGVND SPSLKmAnVGIAMGiNGSDV sKeASDIVLsDDNFaSIlNA vEEGRRMtdNIqKFVLqLLa eNVAqalyLiiGLvFrDenG kSVFpLSPVEvLWiivvTSc FPAMGLGlEkAapDlmdrpP hdsevgIFTwEvIiDtfaYG iimtgscmasFtgslYGins GrLghdCdgtynss...Crd VyrsRSaaFAtmTwCaLilA wEvvdmrrSfFrmhpdtdsp ..vkeffrsiwgNqFLFWSi ifgfvsaFPvVYIPVINdkV FlHkpIGaEWGlaiaftiaF wigaElyKcgKRryfktqr. .ahnpEndlEsnnkrdpfea Yststtihtevnigikq... .................... ....................
(94) Q12691 Saccharomyces cerevisiae ENA5 / ydr038c .........msegtvkennn eefn.......ayhtLttee aaefig.TslteGLtqdesl rrLkavGeNtLgddtkidyk amvlhQvcNAMimVLvIsma IsfavrDWItGGVIsFviav NvliGlvQEyKAtKTMnSLk nLsSPnAhViRnGksetIns kdVVpGDiclvkvGDtiPAD LRLietkNfdTDEsLLTGES LPVsKdanlvfg.keeetsv GDRlNlAfSSSaVvKGRakG IVikTaLnseIGkiAksLqg ds..glisrdpsks...... wlqntwistkkvtgafLGtn vGTPLhRKLskLAvlLFwia vlfAiiVmAsqkfdVdkrVa IYAicVAlSmIPsSLvvVLT ITMsvGaavMvsrnVIVRKL dsLEALGavnDICSDKTGTL TqGKMlaRqiWIPrfGtiti snsddpfnpnegnvsliprf spyeyshnedgdvgilqnfk drlyekdlpedidmdlFqkw LetAtLaNiatvfkd....d atdcWkahGdpTEIAIqVFa tkmdlphnaltgekstnqsn endqsslsqhnekpgsaqfe hiaEfPFDStvKRMSsvyyn nhnetyniYgKGAfEsiisc Csswygk.......dgvkit pLtdcDvetIrknvysLsne GLRVLgFAsksftkdqvndd qlk..nitsnRataEsdLvF lGLiGIYDPPRnEtagaVkk fHqAGInVHMLTGDfvgTAK AIAqEVGIlPtnlyhysqei vdsMvMtgsqFDgLseeevD dLpvLPLVIaRCsPQTKVrM IEALHRRkKFcAMTGDGVND SPSLKmAnVGIAMGiNGSDV sKeASDIVLsDDNFaSIlNA vEEGRRMtdNIqKFVLqLLa eNVAqalyLiiGLvFrDenG kSVFpLSPVEvLWiivvTSc FPAMGLGlEkAapDlmdrpP ndsevgIFTwEvIiDtfaYG iimtgscmasFtgslYGins GrLghdCdgtynss...Crd VyrsRSaaFAtmTwCaLilA wEvvdmrrSfFrmhpdtdsp ..vkeffrsiwgNqFLFWSi ifgfvsaFPvVYIPVINdkV FlHkpIGaEWGlaiaftiaF wigaElyKcgKRryfktqr. .ahnsEndlErsskhdpfea Yststtlqseinisvkh... .................... ....................
95 P78981 Zygosaccharomyces rouxii Z-ENA1 .........mnlnevkend. ...........lfhtLdiaq taqvvg.TdtehGLnaneah arLkhgGpNnLgedtgidyk slvihQvcNAMvmVLfIsmv IsfairDWItGGVIaFvvgv NvsiGvfQEfKAsKTMnSLk sLtSPtAtViReGkhvsves atVVvGDicevrvGDsvPAD LRLveasNfeTDEaLLTGES LPVaKdyqavyd.sdkdtpv GDRlNlAySSSsVvKGRarG IVirTgLdteIGkvAdsLrs kq..tivsrdpaks...... wvvnayrtvhntagafLGtt iGTPLhRKLskLAilLFfia vlfAivVmAsqkfnVdrgVa IYAvcVAlSmIPsSLvvVLT ITMsvGaavMvtrnVlVRsL dsLEALGavtDICSDKTGTL TqGlMvpRqiWvPgfGtvlv esvgk.....dscikiiprl sphefahnndedvgilqdfv nlyndnklpedmqrsyFtqw LdtAaLaNvakvrwd....d ekenWvgqGdpTEvAIqtFv aemg.......greersq.. .................efq nvkEfPFDStiKRMSavfes nqdksrcvYtKGAfEsvldc Ceywygd.......tsggmv pLtekDvegIlnnvdsLssg GLRVLaFAkkvmgkeepie. .........kRskvEagLcF lGLiGIYDPPRpEslgaVkk fHkAGInVHMLTGDfpgTAK AIAqEVGIlPtnlyhypkev vdvMvMtgsqFDsLdenqvD eLpvLPLVIsRCsPQTKVrM IEALHRRgKFcAMTGDGVND SPSLKmAnVGIsMGlNGSDV aKdASDIVLsDDNFsSIlNA vEEGRRMtdNIqKFVLqLLa eNVAealyLvvGLaFqDedG kSVFaLSPVEvLWiivfTSc FPAMGLGlErAapDlmerpP ndssagIFTwEvIfDmigYG vimaavcmgsFttvlYGkda GnLarnCnksytsp...Chd VfraRScaFAtmTwCaLvlA wEvvdmrrSfFrrqpetdep ..crqffrdvyeNkFLFWSi vvgfagaFPvVYIPVINtsV FlHksIGyEWGisigftfvF wigaElwKfgKRlyfrgqar .aqnpEadlEknalhdpfea Ystftsqseilsqkvsh... .................... ....................
- O13397 Debaryomyces occidentalis ENA1 .......mtpsigyvdeden gqkskflrssddpyrLsiee viekfe.ThlenGLsdeqak skLakvGlNnLgadekisis kilahQifNAMvlVLiIsli IalaikDWIsGGVIgFvvfi NifvGfiQElKAeKTMgSLr sLsSPmAralRnGvdsnIna eeVVpGDiihikvGDtiPAD LRLvdcmNleTDEaLLTGES LPVaKdheeiyd.ygapipv GDRlNmAfSSSiVaKGRgtG IVvaTgLdteIGkiAksLkn nddavvvkvdksln.pstkd yliavikttkniifnvLGtn vGTPLqRKLswLAilLFwva vlfAivVmAsqemrVnrnVa IYAicVAlSmIPsSLvvVLT ITMaiGaqvMvtknVIVRKL dsLEALGginDICSDKTGTL TmGKMiaRkvWIPnvGsylv qnsnepfn........ptvg disfnenspk....fiketd deldfiphlpsptpilFekw LhiAtLaNiaslnqiqnemd gsieWeahGdaTEIAInVFt trlg......ytrdkligds ..................le hlnEfPFDSsiKRMStvykd kdgn.stvYtKGAvErvlsc Ckywynp..........elt aLseeDkllIesnmnaLsse GLRVLaFAqreiniskenvs .........nRevvEsnLiF lGLiGIYDPPRpEsaksVkl cHkAGInVHMLTGDhpgTAK AIAqEVGIlPhnlyhyreev vkvMvMianeFDsLsddeiD nLpvLPLVIaRCaPQTKVrM IEALHRRgKFvAMTGDGVND SPSLKkAdVGIAMGlNGSDV aKdASDIVLtDDNFaSIlNA iEEGRRMssNIqKFVLqLLa eNVAqalyLmiGLaFiDksG ySVFpLSPVEvLWiivvTSc FPAMGLGqEkAshDileqpP n...atIFTwEvIiDmiaYG fwmavcclvcFvcivYGkgd GsLgenCnegsdtg...Cnl VfrgRSgaFAafTwCaLllA wEcihlrlSfFkmrpelenp w.wkqlaidlwdNqFLFWSv mgaivsvFPvVYIPVINnkV FlHapIGyEWGlavaftilF ligaEgwKwfKRvyyrksn. .annpEydlErn...dpfke Yssfsksntmeiv....... .................... ....................
- O13398 Debaryomyces occidentalis ENA2 mssintnvaekhsykervnt dasslsadgsveahrLtieq vakifn.TdiinGLstsqan qtLkdfGaNtLgdgdkislt kiiahQvcNAMilVLiIsmv IalaikDWIsGGVIgFvvli NisvGfvQEyKAeKTMgSLr sLsSPtArVtRnGddttIpa eeVVpGDivhikvGDtvPAD LRLidlmNleTDEaLLTGES LPitKnhldvyddysvpipv GDRlNlAySSSvVsKGRgtG IViaTaLdtqIGqiAksLrn nn.svirkvdksngkpkkre yskafcgtikdifyniLGin vGTPLqRKLswLAifLFwgc ryfcnycngipknrVnkeVa IYAicVAlSmIPsaLivVLT ITMavGaqvMvmkhVIVRKL dsLEALGginDICSDKTGTL TqGKMiaRktWIPnvGtfnv gnsndpfn........pkag evsfvnlspk....fieetd eeidfkqklpspfpenFnnw LltAtLaNiatlnqsrdeet gelvWkahGdaTEIAIqVFt srln......ygrdslien. ..................ye hlaEfPFDSsiKRMSavyqs lqtnqikvYtKGAvErvlnc Cthwygheendelydnqqlk eLtddDkhlIesnmnaLstq GLRVLaFAtkditnssidls .........nResiEsnLiF qGLiGIYDPPRpEtagsVks cHnAGInVHMLTGDhpgTAK AIAqEVGIlPhnlyhyseev vkaMcMtaneFDsLsddeiD kLpvLPLVIaRCaPQTKVrM IEALHRRgKFvAMTGDGVND SPSLKkAdVGIAMGlNGSDV aKdASDIVLtDDNFaSIlNA iEEGRRMssNIqKFVLqLLa eNVAqalyLmvGLaFiDdsG lSVFpLSPVEvLWilvvTSc FPAMdLGqErAsdDileesP n...stIFTwEvIiDmivYG fwmavcclvcFviivYGegd pyLgvnCnkssssnsdvCel VfrgRSasFAtmTwCaLilA wEcihpynSlFymrqdtdhp w.wkqtvidlwdNqFLFWSv aigfisvFPvVYIPVINtkV FlHgpIGyEWGlavgfsilF lagsElwKwiKRihkrkank kaknpEyelErs...dpfkk Yasfsrsntmdrpelmv... .................... ....................
Identical in 5 out of 8 sequences ----------------E-N- -------------H-L--E- -A-----T----GL---EA- -RLK--G-N-LG-D-KI--- ----HQVCNAM--VL-ISM- ISFA--DWI-GGVI-FV--- N---G--QEYKA-KTM-SLK -LSSP-A-VIRNGK---I-S --VVPGDI---KVGDT-PAD LRL-E--NFETDEALLTGES LPV-KDA--V---------V GDRLNLA-SSS-V-KGRAKG IVI-T-L-TEIGKIAKSL-- --------RD-S-------- --------TK------LGTN VGTPL-RKLS-LA-LLFWIA VLFAIIVMASQKF-V---VA IYAICVALSMIPSSLVVVLT ITM-VGA-VMV-RNVIVRKL DSLEALG-VNDICSDKTGTL TQGKM-AR--WIP--GT--V -NS--PFN------------ -------N-------L---- --------P-------F--W L-TATLANIATV-------D ----W-AHGDPTEIAIQVF- -----------G-------- -------------------E H--EFPFDS-IKRMS-VY-- --------Y-KGA-E----C C--WYG-------------- -LT--D-E-I--N---LS-E GLRVL-FA-K---K------ ---------NR---ES-L-F LGLIGIYDPPR-E-AGAVK- -H-AGINVHMLTGD--GTAK AIAQEVGILP-NLYHY--E- V--MVMTGSQFD-LS-EEVD -LPVLPLVIARCSPQTKVRM IEALHRRKKF-AMTGDGVND SPSLK-ANVGIAMG-NGSDV -K-ASDIVL-DDNFASILNA VEEGRRM-DNIQKFVLQLLA ENVAQALYL--GL-F-DE-G -SVFPLSPVEVLWIIVVTSC FPAMGLGLE-A-PD-M-RPP ND---GIFTWEVIID---YG --M---C---F---LYG--- G-LG-DCN--Y-S----C-D V-R-RSAAFATMTWCALILA WEV---R-SFFRM-P-TD-P ---K-F----W-NQFLFWSI --GFVS-FPVVYIPVIN-KV FLH-PIG-EWGLA--FTI-F -IGAEL-K--KR-YF--Q-- -A-NPE-DLE-N---DPF-- YST-T--------------- -------------------- --------------------
Identical in 7 out of 8 sequences -------------------- ---------------L---- -------T----GL------ --L---G-N-L--------- -----Q--NAM--VL-I--- I-----DWI-GGVI-F---- N---G--QE-KA-KTM-SL- -L-SP-A-V-R-G----I-- --VV-GD------GD--PAD LRL----N--TDE-LLTGES LPV-K--------------- GDR-N-A-SSS-V-KGR--G IV--T-L---IG--A--L-- -------------------- ----------------LG-- -GTPL-RKL--LA--LF--- ---A--V-A-----V---V- IYA--VA-S-IP-SL--VLT ITM--G---M----VIVRKL --LEALG---DICSDKTGTL T-GKM--R--WIP--G---- -------------------- -------------------- ----------------F--- L--A-L-N------------ ----W---G--TEIAI-VF- -------------------- -------------------- ---E-PFDS--KRMS----- --------Y-KGA-E----- C------------------- -L---D---I------L--- GLRVL-FA------------ ----------R---E--L-F -GL-GIYDPPR-E----V-- -H-AGI-VHMLTGD---TAK AIA-EVGI-P---------- ---M-M----FD-L-----D -L--LPLVI-RC-PQTKV-M IEALHRR-KF-AMTGDGVND SPSLK-A-VGIAMG-NGSDV -K-ASDIVL-DDNF-SI-NA -EEGRRM--NI-KFVL-LL- -NVA----L--GL-F-D--G -SVF-LSPVE-LW----TS- FPAMGLG-E-A--D-----P ------IFT-E-I-D---YG ----------F----YG--- G-L---C----------C-- V---RS--FA--T-C-L--A -E------S-F--------- ------------N-FLFWS- -------FP-VYIPVIN--V F-H--IG-EWG--------F ----E--K--KR-------- -----E---E---------- Y------------------- -------------------- --------------------
Identical in all 8 sequences -------------------- -------------------- ------------G------- ------G-N----------- -----Q--NA---VL----- ------DW---GV------- N---G--QE--A-----SL- ------A---R--------- ---V-GD------G---PAD -R---------DE-LLTGE- LP--K--------------- GDR-N-------V--GR--- -----------G--A--L-- -------------------- -------------------- --T-L--KL------LF--- -------------------- -YA--------P--L--V-- --M------M------VR-L --LE-LG---DICSDKTGT- T---M--------------- -------------------- -------------------- -------------------- L----L-------------- --------G--TE-A----- -------------------- -------------------- ---E--FDS--KRM------ ----------KGA-E----- C------------------- -L---D----------L--- GLR----A------------ ----------R---E--L-F ----GIYDPPR-E----V-- ---AGI-V-MLTGD---TA- -IA----I------------ ----------FD-------D ----L--V--RC-P--KV-M IE-LHRR-----MTGDG-ND SPS-K-A--G--MG--G-DV -K---D-V--DDNF--I--A --EGRR----I--FV--LL- -NV-----L--GL------- -SVF--SP-E-LW----TS- -P---L----A--D-----P -------F----I-D---YG ---------------YG--- ------C----------C-- ----RS--F-------L--- --------S-F--------- ------------N------- --------P--YI--I---- F-H--I--EWG--------- ----E--K------------ -------------------- -------------------- -------------------- --------------------
Conserved segments in all P-type ATPases aa aaaaaaaaaaaaaaaaaaaa aaa bbbbbbbbbb bbbbbbbbbb ccccccccccccc ccccccccccccc d dddddddddddddddddddd ddd eeeeeee eeeeeeeeeeeeeeeeeeee eeeeeeeee ffffffff ffffffffffffffffffff ffffffffffffffffffff fffffffff ggggggggggggggg gggggggggggggggggg ggggggggggggg hhhh hhhhhhhhhhhhhhhhhhhh hhhhhhh
Transmembrane helices 11111111111111 11111 222222222222 2222222 333333333 3333333333 44444444444444444444 44 5555555 5555555555555555 6666666666 666666666 7777 777777777777777777 8888888888888888 8888 999999 99999999999999999 000000000000000 0000
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